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KMID : 0870420090130030152
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Korean Journal of Hepato-Biliary-Pancreatic Surgery
2009 Volume.13 No. 3 p.152 ~ p.157
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Clinical Outcome of 457 Hepatic Resection Cases for the Treatment of Hepatocellular Carcinoma
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Yim Jin-Ho
Kim Sang-Bum
Cho Eung-Ho
Chio Dong-Wook
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Abstract
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Background & Purpose : This purpose of this study was to determine the prognostic factorsfor hepatocellular carcinoma (HCC) in patients who received curative hepatectomies at ourinstitution.Patient and
Method : A retrospective analysis was performed on 457 patients who hadundergone hepatectomies between Mar 1987 and Feb 2008 for HCC at the Korea CancerCenter Hospital, Seoul, Korea. The number of males enrolled in the study was 366 and thenumber of females enrolled was 91. The mean age of the patients was 52.8 years old.Hepatitis B virus-related disease was the most frequent etiology (335/457 patients). Twohundred nine (209) Patients had liver cintiosis, and 93.9% of patients were classified in Child-Pugh Class A.
Result: The complication rate was 30.6% (140/457) and the operative mortality was 1.5%(7/457). Reoperation was performed in 7 complicated patients. Five- and 10-year overallsurvival rates of the patients were 57.7% and 41.8% respectively. Poor prognostic factors ofoverall survival were Child B class, Edmonson-Steiner histologic grade 3 or 4, tumor vascularinvasion, and postoperative complications. Five-and lO-year disease-lree survival rates were42.7% and 32.5%, respectively. Poor prognostic factors for disease free survival included thefollowing an Edmonson-Steiner histologic grade of 3 or 4, tumor vascular invasion, andpostoperative complications.
Conclusion : Postoperative complication is independently a poor prognostic factor for overalland disease free survival in our study. We suggest that special care is needed whileperforming hepatic resections for the treatment of HCC in order to reduce postoperativecomplications.
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KEYWORD
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